{"product_id":"medicinal-rollerball-99-9-pure-dmso-infused-with-organic-comfrey-root-50-dmso-infusion-50-distilled-water-50ml-ships-free-copy","title":"Medicinal Rollerball - 99.9 PURE DMSO infused with ORGANIC DRAGONSBLOOD - 70% DMSO INFUSION 30% DISTILLED WATER- 50ml SHIPS FREE","description":"\u003cp\u003e\u003cem\u003e\u003cstrong\u003eFor more REAL and in-depth info on how this product can benefit you, visit our Instagram @beenefamilyfarm or our Facebook page, Lil Patch of Heaven. The info below is a generalized glimpse of this item, but there is so much more to our products that we cannot post here.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eGlass bottle stainless steel roller ball plastic cap.\u003c\/strong\u003e\u003c\/em\u003e\u003cem\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eThis is a 70% solution of 70% DMSO infused with dragon's blood and 30% distilled water\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDragon’s blood (a natural red tree resin) combined with DMSO (dimethyl sulfoxide) creates a powerful topical treatment used in alternative medicine. DMSO acts as a strong penetration enhancer and anti-inflammatory agent, which helps deliver the resin's wound-healing, antimicrobial, and pain-relieving compounds deep into the tissues\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eKey Medicinal Benefits \u0026amp; UsesWhile scientific studies on this specific combination are limited, both substances individually boast well-documented pharmacological properties that complement each other:Accelerated Wound Healing: Dragon's blood is traditionally used to stop bleeding, promote tissue regeneration, and form a protective \"second skin\". DMSO carries these restorative compounds into skin layers more effectively than water-based suspensions.Pain \u0026amp; Inflammation Relief: Both components act as natural analgesics and anti-inflammatory agents. The mixture is often utilized to relieve symptoms of osteoarthritis, muscle sprains, and joint pain.Antimicrobial Protection: Dragon's blood resin contains polyphenols that fight common pathogens, making this combination a frequent choice in alternative medicine for treating sores, insect bites, and herpetic lesions.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eEthnopharmacological relevance\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDragon׳s blood has been used as a famous traditional medicine since ancient times by many cultures. It is a deep red resin, obtained from more than 20 different species of four distinct genera. Red resin of Dracaena cochinchinensis S.C. Chen, known as Chinese Dragon׳s Blood or Yunnan Dragon׳s Blood, has been shown to promote blood circulation, alleviate inflammation, and to treat stomach ulcers, diarrhea, diabetes, and bleeding. This study investigated an effective approach to identify natural therapeutic agents for neurodegeneration from herbal medicine. The dichloride extract and isolated effective constituents of Chinese Dragon׳s Blood showed quinone oxidoreductase 1 (NQO1) inducing activity and anti-inflammatory effect significantly, which are therapy targets of various neurodegenerative diseases.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMaterials and methods\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMultiple chromatography and spectra analysis were utilized to afford effective constituents. Then Hepa 1c1c7 and BV-2 cells were employed to assay their NQO1 inducing and anti-inflammatory activities, respectively.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eResults\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eBioactivities guided isolation afforded 21 effective constituents, including two new polymers cochinchinenene E (1), cochinchinenene F (2) and a new steroid dracaenol C (16). The main constituent 3 (weight percent 0.2%), 5 (weight percent 0.017%), 4 (weight percent 0.009%), 9 (weight percent 0.094%), 10 (weight percent 0.017%) and 8 (weight percent 0.006%) are responsible for the anti-inflammatory activities of Chinese Dragon׳s Blood. While, new compounds 1, 2 and known compounds 5, 11 showed good NQO1 inducing activities. The brief feature of the activities and structures was discussed accordingly.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eConclusion\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eOverviewing the bioactivities and phytochemical study result, 4'-hydroxy-2,4-dimethoxydihydrochalcone (3) and pterostilbene (5) as effective constituents of Chinese Dragon׳s Blood, were found to be potential candidate therapeutic agents for neurodegenerative diseases.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eGraphical abstract\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eTo screen the novel natural therapeutic agents for neurodegenerative diseases, 21 effective constituents, including two new polymers (1, 2) and a new steroid (16), were identified from Chinese Dragon’s Blood. The main components 3 and 5 were targeted as potential therapeutic agents of neurodegenerative diseases.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003e. Introduction\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eOxidative stress and excessive inflammatory responses in central nervous system (CNS) play critical roles in the pathogenesis of various neurodegenerative diseases such as stroke, Alzheimer׳s disease (AD), Parkinson׳s disease (PD), and Huntington׳s disease (HD), progressive multiple sclerosis (PMS), and amyotrophic lateral sclerosis (ALS) (Gibson and Zhang, 2001, Cho et al., 2012).\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eOxidative stress reflects an imbalance between levels of reactive oxygen species (ROS) and cell׳s ability to scavenge the reactive radicals or to repair the resulted damages. Disturbances in normal redox state of cells can overproduce peroxides and oxygen free radicals that damage components of the cell, including proteins, lipids, and DNA (Menzies et al., 2002, Andersen, 2004, Halliwell, 2006, Barber and Shaw, 2010, Takuya et al., 2012). ROS can be scavenged by antioxidants and antioxidant enzymes, including quinone oxidoreductase 1 (NQO1). There is emerging evidence that NQO1 makes sense in neuroprotective mechanism against oxidative damage (Lee et al., 2012, Lim et al., 2008, Park et al., 2011). NQO1, which has been widely used as a biomarker for activities of phase II antioxidant enzyme, prevents free radical formation from quinone to redox-stable hydroquinone. It has also been shown to protect microglia from oxidative insult (Hwang, 2013, Kim et al., 2013). Therefore, it is a potential therapeutic target for various neurodegenerative diseases (Park et al., 2011).\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eNeuroinflammation is a critical defense mechanism against infectious agents and neuronal injuries in the CNS. However, excessive or sustained neuroinflammatory processes may result in neuronal damages, as observed in many neurodegenerative disorders (Takuya et al., 2012). In response to inflammatory signals, microglia cells, the resident macrophage-like immune cells produce various pro-inflammatory cytokines, including nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 1β (IL-1β), which contribute to progressive damage in the neurodegenerative diseases (Barger and Harmon, 1997; Saleppico et al., 1996). Prevention and mitigation of neurodegenerative diseases are still big challenges after decades of intensive anti-oxidative and anti-inflammatory therapies. New approaches are warranted to identify effective therapeutic agents from naturally occurring phytochemicals.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eIn our screening of natural herbal medicine for therapy of neurodegenerative diseases, the dichloride extract of Chinese Dragon׳s Blood was selected as a good candidate. Dragon׳s blood is a deep red resin, which has been used as a famous traditional medicine since ancient times by many cultures (Gupta et al., 2008). For example, locals of Moomy city on Socotra island used the Dragon’s blood (Dracaena) as a sort of cure-all, using it for things such as general wound healing, a coagulant, curing diarrhoea, lowering fevers, dysentery diseases, internal ulcers of mouth, throat, intestines and stomach, as an antiviral for respiratory and stomach viruses and for skin disorders such as eczema. It is also used for treating dysentery, diarrhoea, hemorrhage and external ulcers in Yemeni folk medicine (Gupta et al., 2008). Dragon’s Blood is obtained from more than 20 different species of four distinct genera Croton, Dracaena, Daemonorops, and Pterocarpus (Gupta et al., 2008, Xina et al., 2011). Red resin of Dracaena cochinchinensis S.C. Chen, known as Yunnan Dragon’s Blood or Chinese Dragon’s Blood has been shown to promote blood circulation, alleviate inflammation, and to treat stomach ulcers, diarrhea, diabetes, and bleeding (Zheng et al., 2006, Gupta et al., 2008, Xina et al., 2011, Yi et al., 2011). Based on the previous work (Li et al., 2012), here we want to clarify the therapeutic effect of Chinese Dragon’s Blood on neurodegenerative diseases and further identify active natural products responsible for the therapeutic effect of the resin.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong class=\"Yjhzub\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 600; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);' style=\"font-size: 1rem;\"\u003eImportant Safety Precautions:\u003c\/strong\u003e\u003cem\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cdiv data-bfc=\"\" class=\"\" data-ved=\"2ahUKEwiNhYOMs6iUAxUTmSYFHQIcEYwQi4wTegQIBRAA\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\n\u003cul class=\"KsbFXc U6u95\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 12px 0px 16px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\n\u003cli class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-hveid=\"CAUQAQ\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 0px 0px 12px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\n\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\u003cstrong class=\"Yjhzub\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 600; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003eExternal Use Only:\u003c!--TgQPHd|[]--\u003e\u003c\/strong\u003e Comfrey should never be ingested as it contains pyrrolizidine alkaloids.\u003c!--TgQPHd|[]--\u003e\u003c\/span\u003e\u003c!--TgQPHd|[]--\u003e\n\u003c\/li\u003e\n\u003cli class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-hveid=\"CAUQAg\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 0px 0px 12px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\u003cspan class=\"T286Pc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 400; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003e\u003cstrong class=\"Yjhzub\" data-sfc-root=\"c\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style='font-family: \"Google Sans\", Roboto, sans-serif; font-size: 16px; font-weight: 600; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);'\u003eApplication Risks:\u003c!--TgQPHd|[]--\u003e\u003c\/strong\u003e DMSO readily absorbs into the skin and may carry impurities with it; ensure the application area is clean. It can cause skin irritation or rashes.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAvoid in Pregnancy: Pregnant women should avoid using DMSO\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow to Use:\u003c\/strong\u003e\u003cbr\u003eMassage a small amount onto clean, dry skin as needed. For best results, use daily\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Choose Us:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e100% Natural Ingredients\u003c\/li\u003e\n\u003cli\u003eFree of Synthetic Fragrances and Preservatives\u003c\/li\u003e\n\u003cli\u003eHandcrafted in Small Batches\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e For external use only. Conduct a patch test before first use, especially for sensitive skin.\u003c\/p\u003e\n\u003cp\u003eDisclaimer: These statements have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. If you are considering making any changes to your lifestyle, diet, or skin care regimen, you should first consult your doctor or healthcare provider. \u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003e\u003cspan data-cid=\"cdeeba32-c3a9-4cc8-ae0d-cbb2f0d87045\" class=\"pjBG2e\"\u003e\u003cspan class=\"UV3uM\"\u003e\u003cstrong\u003eProp65 Warning: \u003c\/strong\u003eThis product can expose you to chemicals which are known to the State of California to cause cancer and birth defects or other reproductive harm.\u003cbr data-end=\"998\" data-start=\"995\"\u003eFor more information, go to \u003ca class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-end=\"1084\" data-start=\"1028\"\u003ewww.P65Warnings.ca.gov\u003cspan class=\"ms-0.5 inline-block align-middle leading-none\" aria-hidden=\"true\"\u003e\u003csvg class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75]\" data-rtl-flip=\"\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M14.3349 13.3301V6.60645L5.47065 15.4707C5.21095 15.7304 4.78895 15.7304 4.52925 15.4707C4.26955 15.211 4.26955 14.789 4.52925 14.5293L13.3935 5.66504H6.66011C6.29284 5.66504 5.99507 5.36727 5.99507 5C5.99507 4.63273 6.29284 4.33496 6.66011 4.33496H14.9999L15.1337 4.34863C15.4369 4.41057 15.665 4.67857 15.665 5V13.3301C15.6649 13.6973 15.3672 13.9951 14.9999 13.9951C14.6327 13.9951 14.335 13.6973 14.3349 13.3301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/span\u003e\u003c\/a\u003e.\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"Default Title","offer_id":46497078214710,"sku":null,"price":48.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0652\/7795\/2054\/files\/PXL_20260604_011602309.jpg?v=1780536595","url":"https:\/\/lilpatchofheaven.org\/products\/medicinal-rollerball-99-9-pure-dmso-infused-with-organic-comfrey-root-50-dmso-infusion-50-distilled-water-50ml-ships-free-copy","provider":"Lil Patch Of Heaven ","version":"1.0","type":"link"}